<code id='9910356314'></code><style id='9910356314'></style>
    • <acronym id='9910356314'></acronym>
      <center id='9910356314'><center id='9910356314'><tfoot id='9910356314'></tfoot></center><abbr id='9910356314'><dir id='9910356314'><tfoot id='9910356314'></tfoot><noframes id='9910356314'>

    • <optgroup id='9910356314'><strike id='9910356314'><sup id='9910356314'></sup></strike><code id='9910356314'></code></optgroup>
        1. <b id='9910356314'><label id='9910356314'><select id='9910356314'><dt id='9910356314'><span id='9910356314'></span></dt></select></label></b><u id='9910356314'></u>
          <i id='9910356314'><strike id='9910356314'><tt id='9910356314'><pre id='9910356314'></pre></tt></strike></i>

          comprehensive

          comprehensive

          author:knowledge    Page View:4138
          Marian F. Moratinos for STAT

          Enticed by the immense market opened by GLP-1 weight loss drugs Wegovy and Zepbound, a handful of biotech companies are trying to develop next-generation, longer-lasting therapies based on a very different approach: RNA interference.

          This Nobel Prize-winning science works by degrading the biological blueprints that RNA use to make proteins — without the genetic instructions, the troublesome proteins are never made and the gene is essentially muted.

          advertisement

          If the companies succeed, it would be a significant shift in the obesity treatment revolution, away from weekly drugs targeting hormones to medications that could be given much less frequently — twice a year or even less — and pinpoint genetic contributors to weight.

          STAT+ Exclusive Story

          Already have an account? Log in

          STAT+

          This article is exclusive to STAT+ subscribers

          Unlock this article — plus daily coverage and analysis of the biotech sector — by subscribing to STAT+.

          Already have an account? Log in

          Already have an account? Log in

          Monthly

          $39

          Totals $468 per year

          $39/month Get Started

          Totals $468 per year

          Starter

          $30

          for 3 months, then $39/month

          $30 for 3 months Get Started

          Then $39/month

          Annual

          $399

          Save 15%

          $399/year Get Started

          Save 15%

          11+ Users

          Custom

          Savings start at 25%!

          Request A Quote Request A Quote

          Savings start at 25%!

          2-10 Users

          $300

          Annually per user

          $300/year Get Started

          $300 Annually per user

          View All Plans

          Get unlimited access to award-winning journalism and exclusive events.

          Subscribe Log In

          explore

          Walensky prepares to leave CDC — and Congress — behind
          Walensky prepares to leave CDC — and Congress — behind

          OutgoingCDCDirectorRochelleWalenskyJIMWATSON/AFPviaGettyImagesRochelleWalensky,theoutgoingdirectorof

          read more
          Why the drug industry's warnings on the IRA's impact fall short
          Why the drug industry's warnings on the IRA's impact fall short

          AdobeEversinceMedicarewasgivenpowertonegotiatepricesforcertainmedicines,thepharmaceuticalindustryhas

          read more
          Bright Health sells Medicare Advantage business to Molina
          Bright Health sells Medicare Advantage business to Molina

          BrightHealthisofficiallyleavingthehealthinsurancemarket.ThecompanyhasagreedtosellitsMedicareAdvantag

          read more

          Free Covid tests will again be offered to all U.S. households

          AdobeThefederalgovernmentisagainofferingfreeCovid-19teststoAmericans,providingafifthroundoffreetests