<code id='03BB115450'></code><style id='03BB115450'></style>
    • <acronym id='03BB115450'></acronym>
      <center id='03BB115450'><center id='03BB115450'><tfoot id='03BB115450'></tfoot></center><abbr id='03BB115450'><dir id='03BB115450'><tfoot id='03BB115450'></tfoot><noframes id='03BB115450'>

    • <optgroup id='03BB115450'><strike id='03BB115450'><sup id='03BB115450'></sup></strike><code id='03BB115450'></code></optgroup>
        1. <b id='03BB115450'><label id='03BB115450'><select id='03BB115450'><dt id='03BB115450'><span id='03BB115450'></span></dt></select></label></b><u id='03BB115450'></u>
          <i id='03BB115450'><strike id='03BB115450'><tt id='03BB115450'><pre id='03BB115450'></pre></tt></strike></i>

          knowledge

          knowledge

          author:explore    Page View:68137
          Marian F. Moratinos for STAT

          Enticed by the immense market opened by GLP-1 weight loss drugs Wegovy and Zepbound, a handful of biotech companies are trying to develop next-generation, longer-lasting therapies based on a very different approach: RNA interference.

          This Nobel Prize-winning science works by degrading the biological blueprints that RNA use to make proteins — without the genetic instructions, the troublesome proteins are never made and the gene is essentially muted.

          advertisement

          If the companies succeed, it would be a significant shift in the obesity treatment revolution, away from weekly drugs targeting hormones to medications that could be given much less frequently — twice a year or even less — and pinpoint genetic contributors to weight.

          STAT+ Exclusive Story

          Already have an account? Log in

          STAT+

          This article is exclusive to STAT+ subscribers

          Unlock this article — plus daily coverage and analysis of the biotech sector — by subscribing to STAT+.

          Already have an account? Log in

          Already have an account? Log in

          Monthly

          $39

          Totals $468 per year

          $39/month Get Started

          Totals $468 per year

          Starter

          $30

          for 3 months, then $39/month

          $30 for 3 months Get Started

          Then $39/month

          Annual

          $399

          Save 15%

          $399/year Get Started

          Save 15%

          11+ Users

          Custom

          Savings start at 25%!

          Request A Quote Request A Quote

          Savings start at 25%!

          2-10 Users

          $300

          Annually per user

          $300/year Get Started

          $300 Annually per user

          View All Plans

          Get unlimited access to award-winning journalism and exclusive events.

          Subscribe Log In

          explore

          Moonlake's readout produced a cash windfall. Risks remain
          Moonlake's readout produced a cash windfall. Risks remain

          MollyFerguson/STATFortwodaysstartingonSunday,MoonlakeImmunotherapeuticshappilycrunchednumbersandshar

          read more
          How the political right came to back psychedelics to treat trauma
          How the political right came to back psychedelics to treat trauma

          FormerTexasGov.RickPerryisamongtheright-wingRepublicanpoliticianswhosupportthedevelopmentofpsychedel

          read more
          How to save PrEP access — and even expand it
          How to save PrEP access — and even expand it

          UndertheAffordableCareAct,healthinsurersarerequiredtocoverallcostsassociatedwithpreventivecare—inclu

          read more

          The history of OxyContin, told through Purdue Pharma documents

          AlexHogan/STATPIKEVILLE,Ky.—STAT’smultiyearlegalbattletounsealsecretPurduePharmafilesinaKentuckycour